Peer Reviewed Articles

Peer-reviewed articles for IPL and LLLT

Shergill M et al. (2024) – A Review of Intense Pulsed Light in the Treatment of Ocular Rosacea

Provides a comprehensive summary of IPL treatments for ocular rosacea symptoms, including eyelid margin irritation and dry eye relief.

Stanford University & USC Study (2021) – Safety and Efficacy of an Augmented IPL Protocol for Dry Eye Syndrome and Blepharitis

Examines a modified IPL approach for dry eye and blepharitis, highlighting safety data.

Toyos R et al. (2015) – Intense Pulsed Light Treatment for Dry Eye Due to MGD; A 3-Year Retrospective Study

One of the first long-term analyses showing sustained benefits of IPL for dry eye.

Craig JP, Chen YH, Turnbull PRK (2015) – Prospective Trial of Intense Pulsed Light for Treatment of MGD

A randomized controlled trial demonstrating efficacy for meibomian gland dysfunction.

BMC Ophthalmology (2022) – A Retrospective Study of IPL via Lacrystim® for MGD Therapy

Reports positive outcomes using the Lacrystim IPL device; calls for RCTs.

Wiley/Acta Ophthalmologica (2024) – IPL Meta-Analysis for Dry Eye Due to MGD

Pooled data from 13 RCTs showed significant symptom improvement (OSDI score drop ~16 points vs placebo).

Springer Ophthalmology & Therapy (2022) – Efficacy & Safety of New-Gen IPL for MGD‑Related Dry Eye

A multicenter, randomized, non-inferiority trial of a next-gen Eyesis IPL device.

MDPI Journal Medicines (2021) – MGD: Combined IPL + LLLT as Rescue Treatment

Retrospective study detailing a combined IPL + LLLT protocol using Eye-light®.

MeibomianGlandIssues (2023) – A Randomized, Controlled Study Evaluating IPL + LLLT for MGD/Evaporative Dry Eye

Preliminary results comparing combined therapy vs standalone IPL, showing promising outcomes.

MeibomianGlandIssues (2023) – Low‑Level Light Therapy Before/After Cataract Surgery for Dry Eye

A double-masked RCT demonstrating efficacy of LLLT in mitigating postoperative dry eye signs.